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Jun-Ichi Shishikura Selected Research

2- (N- (4- chlorophenyl)- N- methylamino)- 4H- pyrido(3,2- e)- 1,3- thiazin- 4- one

1/2019Synthesis and Pharmacological Evaluation of 3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile Derivatives as Orally Active AMPA Receptor Antagonists.
8/2004Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats.
1/2004Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and rats.

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Jun-Ichi Shishikura Research Topics

Disease

3Seizures (Absence Seizure)
01/2019 - 01/2004
2Neuralgia (Stump Neuralgia)
08/2015 - 08/2015
1Hyperalgesia
08/2015
1Temporal Lobe Epilepsy
08/2004
1Epilepsy (Aura)
08/2004
1Infarction (Infarctions)
01/2002
1Ischemia
01/2002
1Ischemic Stroke
01/2002
1Stroke (Strokes)
01/2002

Drug/Important Bio-Agent (IBA)

32- (N- (4- chlorophenyl)- N- methylamino)- 4H- pyrido(3,2- e)- 1,3- thiazin- 4- oneIBA
01/2019 - 01/2004
3AMPA Receptors (AMPA Receptor)IBA
08/2004 - 01/2002
2N-Type Calcium Channels (N-Type Calcium Channel)IBA
08/2015 - 08/2015
2Anticonvulsants (Antiepileptic Drugs)IBA
08/2004 - 01/2004
2Carbamazepine (Tegretol)FDA LinkGeneric
08/2004 - 01/2004
2Diazepam (Valium)FDA LinkGeneric
08/2004 - 01/2004
2Phenobarbital (Luminal)FDA Link
08/2004 - 01/2004
2Phenytoin (Dilantin)FDA LinkGeneric
08/2004 - 01/2004
2Ethosuximide (Zarontin)FDA LinkGeneric
08/2004 - 01/2004
1talampanelIBA
01/2019
1Valproic Acid (Depakote)FDA LinkGeneric
08/2004
1Kainic Acid (Kainate)IBA
08/2004
1Lamotrigine (Lamictal)FDA LinkGeneric
01/2004
1alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA
01/2004
1Gabapentin (Neurontin)FDA LinkGeneric
01/2004
1YM 872IBA
01/2002
1Pharmaceutical PreparationsIBA
01/2002
1Neuroprotective AgentsIBA
01/2002

Therapy/Procedure

2Ligation
08/2015 - 08/2015
2Oral Administration
08/2015 - 08/2015